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2025, 05, v.38 7-11
抗性淀粉对慢性疾病肠道菌群功能影响的研究进展
基金项目(Foundation): 非粮生物质能技术全国重点实验室开放基金(SKL-NFBET-2025-21); 海南省重点研发项目(ZDYF2019031)
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DOI:
摘要:

介绍抗性淀粉调节和改善肠道微生物群的机制及其对慢性疾病发生和发展的影响,并总结抗性淀粉与一些常见慢性病肠道菌群关系的研究进展,旨在为后续开展抗性淀粉作用于相关疾病与肠道菌群研究提供参考。

Abstract:

The regulatory mechanisms of resistant starch in modulating and improving intestinal microbiota, and its impact on the onset and progression of chronic diseases were introduced. The research progress of the relationship between resistant starch and intestinal microbiota of some common chronic diseases were reviewed, aiming to provide valuable reference for subsequent investigations into the effects of resistant starch on related diseases and intestinal microbiota.

参考文献

[ 1 ] MA Q T,LI Y Q,LI P F,et al.Research progress in the relationship between type 2 diabetes mellitus and intestinal flora[J].Biomedicine & Pharmacotherapy,2019,117:109138.

[ 2 ] 章磊,姚迪,陆卫平.肠道菌群代谢物与糖尿病肾病[J].医学综述,2021,27(21):4292-4299.

[ 3 ] 王扶香,莫剑慧,胡新中,等.肠道菌群对抗性淀粉的降解机制[J].中国食品学报,2024,24(1):364-378.

[ 4 ] 钱映,冯月梅,汪艳姣,等.肠道菌群与慢性病关系的研究进展[J].中国微生态学杂志,2022,34(10):1217-1221.

[ 5 ] WEN J J,LI M Z,HU J L,et al.Resistant starches and gut microbiota [J].Food Chemistry,2022,387:132895.

[ 6 ] 梁单.马铃薯抗性淀粉调节肠道菌群及改善肥胖的作用机制[D].北京:中国农业科学院,2021.

[ 7 ] WANG Z G,WANG S L,XU Q H,et al.Synthesis and functions of resistant starch [J].Advances in Nutrition,2023 ,14(5):1131-1144.

[ 8 ] LIU J M,LU W,LIANG Y T,et al.Research progress on hypoglycemic mechanisms of resistant starch:A review[J].Molecules,2022,27(20):7111.

[ 9 ] WANG R,LI M,STRAPPE P,et al.Preparation,structural characteristics and physiological property of resistant starch [J].Advances in Food and Nutrition Research,2021,95:1-40.

[10] 王安琪.抗性淀粉饮食配方对肥胖鼠的营养干预[D].天津:天津科技大学,2020.

[11] WANG S J,CHAO C,CAI J J,et al.Starch-lipid and starch-lipid-protein complexes:A comprehensive review[J].Comprehensive Reviews in Food Science and Food Safety,2020,19(3):1056-1079.

[12] LI C,HU Y M.New definition of resistant starch types from the gut microbiota perspectives-a review[J].Critical Reviews in Food Science and Nutrition,2023,63(23):6412-6422.

[13] 张金秀,胡新中,马蓁.不同类型抗性淀粉的多尺度结构特征与肠道菌群调节功能研究进展[J].食品科学,2022,43(17):24-35.

[14] ZHOU Y M,ZHAO S,JIANG Y,et al.Regulatory function of buckwheat-resistant starch supplementation on lipid profile and gut microbiota in mice fed with a high-fat diet[J].Journal of Food Science,2019,84(9):2674-2681.

[15] ZHU Y Y,DONG L E,HUANG L,et al.Effects of oat β-glucan,oat resistant starch,and the whole oat flour on insulin resistance,inflammation,and gut microbiota in high-fat-diet-induced type 2 diabetic rats[J].Journal of Functional Foods,2020,69:103939.

[16] KEMP J A,PAIVA B R D,SANTOS H F D,et al,The impact of enriched resistant starch type-2 cookies on the gut microbiome in hemodialysis patients:A randomized controlled trial[J].Molecular Nutrition & Food Research,2021,65(19):e2100374.

[17] HUGHES R L,HORN W H,FINNEGAN P,et al.Resistant starch type 2 from wheat reduces postprandial glycemic response with concurrent alterations in gut microbiota composition[J].Nutrients.2021,13(2):645.

[18] LI Z T,HU G A,ZHU L,et al.In vitro digestion and fecal fermentation of highly resistant starch rice and its effect on the gut microbiota[J].Food Chemistry,2021,361:130095.

[19] LAFFIN M R,KHOSROSHAHI H T,PARK H,et al.Amylose resistant starch (HAM-RS2) supplementation increases the proportion of Faecalibacterium bacteria in end-stage renal disease patients:Microbial analysis from a randomized placebo-controlled trial[J].Hemodialysis International,2019,23(3):343-347.

[20] 季芳妃.重结晶型抗性淀粉对2型糖尿病小鼠降血糖作用及其机制研究[D].青岛:青岛大学,2023.

[21] LIANG D,ZHANG L,CHEN H Z,et al.Potato resistant starch inhibits diet-induced obesity by modifying the composition of intestinal microbiota and their metabolites in obese mice[J].International Journal of Biological Macromolecules,2021,180:458-469.

[22] WANG M M,WICHIENCHOT S,HE X W,et al.In vitro colonic fermentation of dietary fibers:Fermentation rate,short-chain fatty acid production and changes in microbiota[J].Trends in Food Science & Technology,2019,88:1-9.

[23] GOPALSAMY G,MORTIMER E,GREENFIELD P,et al.Resistant starch is actively fermented by infant faecal microbiota and increases microbial diversity[J].Nutrients,2019,11(6):1345.

[24] QIN R B,WANG J,CHAO C,et al.RS5 produced more butyric acid through regulating the microbial community of human gut microbiota[J].Journal of Agricultural and Food Chemistry,2021,69(10):3209-3218.

[25] LIU H C,ZHANG M,MA Q Y,et al.Health beneficial effects of resistant starch on diabetes and obesity via regulation of gut microbiota:A review[J].Food & Function,2020,11(7):5749-5767.

[26] CHANG R R,LIU J,JI F F,et al.Hypoglycemic effect of recrystallized resistant starch on high-fat diet-and streptozotocin-induced type 2 diabetic mice via gut microbiota modulation[J].International Journal of Biological Macromolecules,2024,261:129812.

[27] 武学慧,薛君,贺佳丽,等.抗性淀粉对2型糖尿病肥胖大鼠肠道菌群及代谢影响的研究[J].中国糖尿病杂志,2024,32(9):695-702.

[28] PAN X,LIU P,ZHANG Y J,et al.Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota[J].International Journal of Biological Macromolecules,2023,253:126930.

[29] SONG X Q,DONG H H,ZANG Z Z,et al.Kudzu resistant starch:An effective regulator of type 2 diabetes mellitus[J].Oxidative Medicine and Cellular Longevity,2021,2021:4448048.

[30] GONDALIA S V,WYMOND B,BENASSI-EVANS B,et al.Substitution of refined conventional wheat flour with wheat high in resistant starch modulates the intestinal microbiota and fecal metabolites in healthy adults:A randomized,controlled trial[J].The Journal of Nutrition,2022,152(6):1426-1437.

[31] ZHANG L,OUYANG Y,LI H T,et al.Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects:A randomized crossover trial[J].Scientific Reports,2019,9(1):4736.

[32] ZHANG W Y,ZHANG N N,GUO X X,et al.Potato resistant starch type 1 promotes obesity linked with modified gut microbiota in high-fat diet-fed mice[J].Molecules,2024,29(2):370.

[33] 傅金凤,谭思敏,涂师运,等.5种食品原料对高脂饮食诱导的肥胖大鼠肠道菌群和短链脂肪酸的影响(英文)[J].食品科学,2022,43(13):89-100.

[34] 汪雨亭.香蕉抗性淀粉的减肥功能及其对肠道菌群的影响研究[D].广州:华南理工大学,2018.

[35] LI H T,ZHANG L,LI J,et al.Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota[J].Nature Metabolism.2024,6(3):578-597.

[36] 张蕾.抗性淀粉对肥胖的干预效果和分子机制研究[D].上海:上海交通大学,2019.

[37] WANG B,LIU J T,LEI R Y,et al.Cold exposure,gut microbiota,and hypertension:A mechanistic study[J].Science of the Total Environment,2022,833:155199.

[38] JIN L,SHI X M,YANG J,et al.Gut microbes in cardiovascular diseases and their potential therapeutic applications[J].Protein & Cell,2021,12(5):346-359.

[39] O′DONNELL J A,ZHENG T H,MERIC G,et al.The gut microbiome and hypertension[J].Nature Reviews Nephrology,2023,19(3):153-167.

[40] NAKAI M,RIBEIRO R V,STEVENS B R,et al.Essential hypertension is associated with changes in gut microbial metabolic pathways:A multisite analysis of ambulatory blood pressure[J].Hypertension,2021,78(3):804-815.

[41] JIANG S,SHUI Y J,CUI Y,et al.Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension[J].Redox Biology,2021,46:102115.

[42] KAYE D M,SHIHATA W A,JAMA H A,et al.Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease[J].Circulation,2020,141(17):1393-1403.

[43] MOLEóN J,GONZáLEZ-CORREA C,MI?ANO S,et al.Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation[J].Pharmacological Research,2023,198:106997.

[44] JAMA H A,RHYS-JONES D,NAKAI M,et al.Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial[J].Nature Cardiovascular Research,2023,2(1):35-43.

[45] RHYS-JONES D,CLIMIE R E,GILLP A,et al.Microbial interventions to control and reduce blood pressure in Australia (MICRoBIA):Rationale and design of a double-blinded randomised cross-over placebo controlled trial[J].Trials,2021,22(1):496.

[46] 首第文.抗性淀粉通过肠道菌群改善非酒精性脂肪肝病的作用及其机制研究[D].广州:华南理工大学,2021.

[47] YE Q,ZOU B Y,YEO Y H,et al.Global prevalence,incidence,and outcomes of non-obese or lean non-alcoholic fatty liver disease:A systematic review and meta-analysis[J].The Lancet Gastroenterology & Hepatology,2020,5(8):739-752.

[48] RONG L,ZOU J Y,RAN W,et al.Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)[J].Frontiers in Endocrinology,2023,13:1087260.

[49] 耿妍,鲁晓岚,耿燕,等.肠道菌群紊乱在大鼠非酒精性脂肪肝中的作用机制[J].分子诊断与治疗杂志,2020,12(12):1626-1630.

[50] 钱映,冯月梅,汪艳姣,等.肠道菌群与慢性病关系的研究进展[J].中国微生态学杂志,2022,34(10):1217-1221.

[51] TRIPATHI A,DEBELIUS J,BRENNER D A,et al.The gut-liver axis and the intersection with the microbiome[J].Nature Reviews Gastroenterology & Hepatology,2018,15(7):397-411.

[52] 钱玲玲.非酒精性脂肪性肝病的诊断及抗性淀粉对其的干预研究[D].上海:上海交通大学,2020.

[53] NI Y Q,QIAN L L,SILICEO S L,et al.Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations[J].Cell Metabolism,2023,35(9):1530-1547.

基本信息:

DOI:

中图分类号:TS201.4;TS231

引用信息:

[1]何冰冰,方桂红,陈雨蓓等.抗性淀粉对慢性疾病肠道菌群功能影响的研究进展[J].粮食与油脂,2025,38(05):7-11.

基金信息:

非粮生物质能技术全国重点实验室开放基金(SKL-NFBET-2025-21); 海南省重点研发项目(ZDYF2019031)

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